منابع مشابه
Early replication for short telomeres
L ike fi rst-class airline passengers, short telomeres get preferential treatment. They cut to the front of the line during DNA replication, according to Alessandro Bianchi and David Shore (University of Geneva, Switzerland). The shortening of telomeres with each cell division is counteracted by telomerase, which extends these repetitive sequences that cap the ends of linear chromosomes. The sq...
متن کاملAt Short Telomeres Tel1 Directs Early Replication and Phosphorylates Rif1
The replication time of Saccharomyces cerevisiae telomeres responds to TG1-3 repeat length, with telomeres of normal length replicating late during S phase and short telomeres replicating early. Here we show that Tel1 kinase, which is recruited to short telomeres, specifies their early replication, because we find a tel1Δ mutant has short telomeres that nonetheless replicate late. Consistent wi...
متن کاملEarly Replication of Short Telomeres in Budding Yeast
The maintenance of an appropriate number of telomere repeats by telomerase is essential for proper chromosome protection. The action of telomerase at the telomere terminus is regulated by opposing activities that either recruit/activate the enzyme at shorter telomeres or inhibit it at longer ones, thus achieving a stable average telomere length. To elucidate the mechanistic details of telomeras...
متن کاملTel1 dictates the replication timing of short yeast telomeres
Running title: Tel1 ATM specifies telomere replication timing
متن کاملTel1ATM dictates the replication timing of short yeast telomeres
Telomerase action is temporally linked to DNA replication. Although yeast telomeres are normally late replicating, telomere shortening leads to early firing of subtelomeric DNA replication origins. We show that double-strand breaks flanked by short telomeric arrays cause origin firing early in S phase at late-replicating loci and that this effect on origin firing time is dependent on the Tel1(A...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2007
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1772rr2